What is Semaglutide?
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). It mimics the GLP-1 hormone, which is released in the gut in response to eating.
One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose). For that reason, healthcare providers have used semaglutide for more than 15 years to treat Type 2 diabetes.
However, GLP-1 in higher amounts also interacts with the parts of the brain that suppress your appetite and signal you to feel complete. When used in conjunction with diet and exercise, it can cause significant weight loss — and a reduced risk of cancer, diabetes, and heart disease — in people who are obese or overweight.
Semaglutide Injections for Weight Loss
Currently, semaglutide is only approved for weight loss under the brand name Wegovy. The typical dose is 2.4 milligrams, administered weekly as subcutaneous (under the skin) self-injections.
However, as interest in semaglutide for weight loss grows, healthcare professionals are finding ways to manage the demand. Many prescribe other brands of semaglutide, such as Ozempic and Rybelsus, off-label (using a drug that is FDA-approved for a different reason).
“Many people use semaglutide off-label to help manage weight,” Dr. Surampudi says. “The demand has become so high that now there is a shortage for people who need this medication to help manage their diabetes.”
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