What is Daxxify?
Daxxify (daxibotulinumtoxinA-lanm) is the first Botox alternative free of human albumin or animal-based components, and it was FDA-approved in September 2022. It is also the longest-lasting of all cosmetic injectable wrinkle treatments, lasting for 6 months in most people and 9 months in some. Daxxify is made by Revance Therapeutics Inc., and the formulation uses a patented, innovative, cell-penetrating peptide technology (called Peptide Exchange Technology) consisting of a man-made 35-amino acid stabilizing excipient with a highly positive charge.
Although Daxxify lasts longer than Botox, it is only currently approved to treat glabella lines and adults with cervical dystonia (a rare muscle disorder that causes neck spasms and twisting). Botox Cosmetic has the approval to treat frown lines, crow’s feet lines, and forehead lines, and Botox has the approval to treat several medical conditions like chronic migraines, specific bladder issues, excessive sweating, and other muscle-related problems.
How often does Daxxify need to be injected?
Daxxify only needs two treatments a year to give year-long results because the average duration of effect is six months. In some people, Daxxify lasts for nine months, while Botox only lasts for three to four months.
Clinical trials reported that 80 percent of people using Daxxify had no or minimally visible facial wrinkles after four months, with approximately 50% having little evidence of wrinkles at six months.
What is Daxxify FDA-approved for?
Currently, Daxxify is only FDA-approved for treating glabella lines – the short vertical skin lines that appear between the eyebrows and above the nose. These are usually the first wrinkles to appear on the forehead.
What is the recommended dosage for Daxxify?
Daxxify is usually given as five equal intramuscular injections of 8 units each (two injections into each corrugator muscle and one into the procerus muscle) for a total recommended dose of 40.
